Electroretinographic Study of the C57BL/6-mi/mi Mouse Model of Retinal Degeneration
نویسندگان
چکیده
Results. The mean of the maximum b-wave amplitude (Vmax) at 4 weeks was 234 ± 1 4 /*V in mi "/mi" mice, which did not differ significantly from controls (266 ± 26 /iV). With increasing age, all components of the ERG decreased and by 12 weeks, the mean of the Vmax had decreased to 170 jt*V. At 18 weeks, the mean Vmax was 75 /xV, and the bto a-wave ratio was still > 1.0. Comparison of these physiologic data to previously reported morphologic and biochemical data showed a high correlation between the b-wave amplitude and the number of photoreceptor cell nuclei (r = 0.9772) as well as the b-wave amplitude and rhodopsin levels (r = 0.9019).
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